M6A-seq & RNA-seq analysis of wild type and Mettl3-cKO liver tissues' or hepatocytes' transcriptomes

To investigate the role of METTL3-mediated m6A modification in liver, we performed m6A-sequencing and RNA-seq to map the m6A modification and gene expression in liver tissues or hepatocytes of wild type (WT) and liver-sepcific Mettl3-KO mice. Overall design: m6A-seq and transcriptome profiles of liver in 8 weeks wild type (WT) and liver-sepcific Mettl3-KO mice were generated by deep sequencing,with biologic replicates. In addtion, m6A-seq and transcriptome profiles of hepatocytes in 8 weeks wild type (WT) and liver-sepcific Mettl3-KO mice were generated by deep sequencing,too.