This study examined large renal tubule extracellular vesicles (LRT-EVs) isolated from urine of a 5/6 nephrectomy (5/6Nx) rat model that recapitulates many elements of human chronic kidney disease (CKD
To explore the impact of miR-214 expression in vascular endothelial cells on renal inflammation and glomerulosclerosis in 5/6 nephrectomized mice, transcriptomic profiling was conducted on mouse aorti
*: p<0.05 vs. vehicle treated CRF rats, same time point. °: p<0.05 vs. week 0, same treatment group. Serum biochemistry of vehicle versus 185 mg/kg CaMg treated adenine-induced CRF rats.
Background: Patients with chronic kidney disease (CKD) have very high levels of uncarboxylated, inactive, extra-hepatic vitamin K-dependent proteins measured in circulation, putting them at risk for c