Distinct miR Expression Signatures of Primary and Secondary CNS Lymphomas

FFPE brain biopsy specimens of 64 patients with primary central nervous system lymphoma and 9 patients with secondary central nervous system lymphoma were analyzed in the study. We used the NanoSting nCounter human v3 miRNA assay for characterizing miRNA expression and carried out a detailed differential expression and clustering analysis of samples and miRNAs to look for expression changes associated to primary or secondary origin, cell of origin, mutation status or survival. FFPE brain biopsy specimens of 64 patients with primary central nervous system lymphoma (PCNSL) and 9 patients with secondary central nervous system lymphoma (SCNSL) were analyzed in this study. Tissue samples were obtained from three different centers.