List of positions located in the 7-TMs and EL2 of rhodopsin (Rho).

beta-2 adrenergic receptor (��2-AR) and adenosine receptor (A2A) that are in contact with the co-crystallized ligand (underlined) and/or qualified as key positions (in bold and marked with an X). The MI data refer to the analysis performed on a subset of class A receptor adding to the MSA of the 7-TMs the alignment of five EL2 positions. The position has highest MI (among all other inter-TM positions) with the listed pair position (pp). Rank is the MI ranking of that pair using a subset of class A 7-TM along with EL2 MSA (249 sequences) the degree is calculated using MI graph from top 700 MI pairs. Entropy and MI are measured in bits.