Supplementary Material for: Cutaneous Rosai-Dorfman Disease: A report of 2 cases and a Review of Recent Literature (2018–2023)

Rosai-Dorfman Disease (RDD) is a rare, benign histiocytic disorder that can present as isolated cutaneous Rosai-Dorfman disease (CRDD), often mimicking other dermatologic conditions and complicating diagnosis. We report two cases of CRDD: one with the palms and soles involvement, and another as an exophytic facial mass, initially misdiagnosed and unsuccessfully treated. Dermoscopy revealed distinctive features, including yellow ovoid structures, linear vessels, and cotton-like white globules. Histopathological and immunohistochemical analyses confirmed CRDD with histiocytic infiltration and emperipolesis, key histological markers of CRDD.
A review of 53 cases (2018–2023) highlights CRDD’s clinical variability, common anatomical sites, and diverse treatment responses, emphasizing the need for individualized management and early recognition for optimal treatment. These findings contribute to a broader understanding of CRDD and support a multidisciplinary approach to optimizing patient care.