Strand bias.

1The strand preference score and association statistic was calculated in a manner similar to Pedersen et al. (2005)[8]. RNAz scores were evaluated on both strands. Each position was assigned a strand preference score depending on if the higher score was on the sense strand (strand preference score = 1), the antisense strand (strand preference score = 0), or if the scores on the two strands were equal (strand preference score = 0.5). This association statistic was assumed to be binomial distributed with parameter p = 0.5. The alternate hypothesis is that p deviates from 0.5.