Metainteractome functional and disease enrichment analysis

This dataset contains all scripts and input data used for the Meta-interactome (HuMMI) analysis, encompassing both interspecies and intraspecies interaction investigations. The materials provided enable full reproducibility of the computational workflow and cover multiple analytical components, including: Interspecies and intraspecies convergence analysis Functional enrichment analysis of human proteins targeted by commensal effecgtors Trait enrichment analysis – Assessment of associations between human proteins targeted by commensal effectors and phenotypic traits documented in Open Targets. Effector sequence similarity and interaction profile similarity – Comparative analysis of effector protein sequences and their interaction patterns AlphaFold (AF) interface similarity analysis – Structural comparison of predicted protein–protein interaction interfaces to evaluate conservation and variation at the 3D structural level. Analysis scripts – scripts for each analytical stage Data files – Processed datasets and required reference files to run the workflows.