Molecular and Genetic Crosstalks Between mTOR and ERRa are Key Determinants of Rapamycin-induced Non-Alcoholic Fatty Liver.

mTOR and ERRa are key regulators of common metabolic processes. However, the extent of functional overlap between these two factors has not been investigated. ChIP-sequencing analyses on mouse liver reveal mTOR recruitment to regulatory regions of genes on a genome-wide scale including enrichment at genes shared with ERRa that are involved in the TCA cycle and lipogenesis pathway. A total of 9469 and 23226 peaks were identified for mTOR and ERRa ChIP-seq datasets, respectively. Overall design: mTOR and ERRa mouse liver ChIP-seq datasets obtained from pooling 8 individual ChIPs from a chromatin pool of 26 livers.