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KPC-2 N170A mutant bound to hydrolyzed imipenem at 2.05 A

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Protein Data Bank Japan2024-10-16 更新2026-03-21 收录
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https://pdbj.org/mine/summary/6xj8
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KPC-2 N170A mutant bound to hydrolyzed imipenem at 2.05 A Descriptor: (2R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-(2-methanimidamidoethylsulfanyl)-2,3-dihydro-1H-pyrrole -5-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC Authors: Pemberton, O.A, Chen, Y. Deposit date: 2020-06-23 Release date: 2020-12-09 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.05 Å) Cite: KPC-2 beta-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J.Biol.Chem., 296, 2020
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2020-06-23
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