Expression data from CD115+ preosteoclasts stimulated by conditioned medium from CT-26 cells. Expression data from CD115+ preosteoclasts stimulated by conditioned medium from CT-26 cells

In osteolytic tumor, bone resportion can be occured after bone metastasis. Bone metastasis of colorectal cancer can induce obvious bone destruction. Aberrant activation of osteoclasts and the precursors is responsible for tumor-induced osteolysis. The biological process of osteoclast precursors could be modified by different tumor microenvironment. Microarrays were used to detail the differentially expressed genes or non-coding RNAs between normal osteoclast precursors and osteoclast precursors treated by secreta from CT-26 cells. Overall design: We sorted out primary osteoclast precursors labelled with CD115. CD115+ osteoclast precursors were treated by conditioned medium from colorectal cancer cell line, CT-26 or normal culture medium.