<b>Causal Relationships Between Gut Microbiota, Plasma Metabolites, and Hemorrhoidal Disease: Insights from Mendelian Randomization</b>

Table S1: Instrumental variables of gut microbiota after clumping and exclusion of week IVs; Table S2: Instrumental variables of plasma metabolites after clumping and exclusion of week IVs; Table S3: Causal effects of gut microbiota on MD (Forward MR analysis); Table S4: Causal effects of hemorrhoids on identified gut microbiota (Reverse MR analysis); Table S5: Genetic correlation between identified gut microbiota and hemorrhoids (LDSC analysis); Table S6: Causal associations between plasma metabolites and hemorrhoids (Associations only with PIVW less than 0.05 and consistent with all sensitivity analysis were listed); Table S7: Causal associations between identified gut microbiota and 46 plasma metabolites; Table S8: Mediation analysis between gut microbiota, plasma metabolites, and hemorrhoids.