Study Sample Demographics.

1The ACFBAL sample has a higher frequency of F508del homozygotes than other samples (ANOVA p2The CFF sample has a lower proportion of Non-Hispanic Whites than other samples (ANOVA p = 0.002). 3CFF and ACFBAL samples diagnosed at older and younger ages, respectively, than other samples (ANOVA p4The CFTSS sample has a younger age of pulmonary function testing than other samples (ANOVA p5All samples differ from each other by age of last respiratory culture (ANOVA p6Definition of secondhand smoke for the CFTSS sample (ever having been exposed) differs from the CFF sample definition (exposure within the past year (2007)). 7CFTSS and CFF samples are statistically different (T test or chi square p8Mean temperatures of ACFDR and ACFBAL samples are not statistically different (T test p = 0.34). 9The ACFDR sample has a higher prevalence of P. aeruginosa than the CFF and ACFBAL samples, and the CFTSS sample has a higher prevalence than all other samples (ANOVA p10The ACFBAL sample has an earlier age of acquisition than the CFTSS sample (ANOVA p11The CFF sample has a lower prevalence of B. cepacia complex than other samples (ANOVA p12All samples differ by mean lung function (ANOVA p