Stable 5-Hydroxymethylcytosine (5hmC) Acquisition Marks Gene Activation During Chondrogenic Differentiation [seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE64150
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资源简介：
Regulation of chondrogenic differentiation by DNA demethylation is little understood. The ten-eleven-translocation (TET) proteins oxidize methylated cytosines (5mC) to 5hmC, 5fC and 5caC eventually leading to DNA demethylation. However, 5hmC is stable and can potentially act as an epigenetic mark as well. Here, we report that global changes in 5hmC mark chondrogenic differentiation. Examination of changing 5hmC levels in progenitor and differentiated chondrocytes.
创建时间：
2019-05-15
