Dynamic Kinetic Cross-Coupling Strategy for the Asymmetric Synthesis of Axially Chiral Heterobiaryls
收藏NIAID Data Ecosystem2026-03-08 收录
下载链接：
https://figshare.com/articles/dataset/Dynamic_Kinetic_Cross_Coupling_Strategy_for_the_Asymmetric_Synthesis_of_Axially_Chiral_Heterobiaryls/2363617
下载链接
链接失效反馈官方服务：
资源简介：
A dynamic
kinetic asymmetric transformation (DYKAT) technique has
been designed for the synthesis of 2′-substituted 2-aryl pyridines/isoquinolines
and related heterobiaryls. In this way, the Pd(0)-catalyzed
coupling of racemic 2-triflates with aryl boroxines using a TADDOL-derived
phosphoramidite as the ligand provides the corresponding coupling
products with good to excellent enantioselectivities. Structural studies
support that the formation of configurationally labile oxidative addition
palladacycles is the key for the success of the methodology.
创建时间：
2013-10-23
