Radiological features of gait phenotypes in patients with idiopathic normal pressure hydrocephalus

Introduction

This database includes the raw data linked with the paper “ Radiological features of gait phenotypes in patients with idiopathic normal pressure hydrocephalus  ” in submission.

In this paper, we reported radiological and clinical aspects of a patient’s cohort with possible or probable iNPH, divided in two different groups based on gait disorder phenotypes. We aimed to understand the neuroimaging correlates of iNPH phenotyping into different gait patterns, by assessing specific radiological features and their correlations with clinical scores.

Methods

We enrolled 86 probable iNPH patients (53 males; age range: 69–88 years), who underwent a comprehensive clinical assessment, including neuropsychological tests, and a conventional MRI scan. Cohort was subdivided into disequilibrium subtype (29 subjects) and locomotor subtype of HLGD (57 patients) based on gait evaluation. We compared the iNPH subtypes assessing differences in eight linear radiological indexes and their clinical correlates.

Results

The Height of the Third Ventricle was the only radiological feature that differed between the two motor phenotypes (p < 0.05), being higher in the locomotor subtype and showing a trend of correlation with the motor score of the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale and with the continence score of the iNPH Rating Scale. Among several clinical-radiological correlations, a reduced callosal angle correlated with the severity of motor and urinary symptoms (p < 0.05).