首页/数据集/Budding yeast ATM/ATR contribute to meiotic double-strand-break (DSB) homeostasis by down-regulating Rec114, an essential component of the DSB-machinery

Budding yeast ATM/ATR contribute to meiotic double-strand-break (DSB) homeostasis by down-regulating Rec114, an essential component of the DSB-machinery

Alliance of Genome Resources2026-08-01 收录

减数分裂调控

同源重组机制

数据链接：

https://www.yeastgenome.org/dataset/GSE43384 数据链接链接失效反馈

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资源简介：

In most organisms, meiotic recombination begins with programmed DNA double strand break (DSB) formation by Spo11

应用场景：

减数分裂调控

细胞周期蛋白激酶功能

Meiosis is an important process in sexual reproduction. Meiosis initiation has been found to be highly diverse among species. In yeast, it has been established that cyclin-dependent kinases (Cdks) and

Figshare2016-07-15 更新10

FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks

DNA双链断裂修复

同源重组机制

FANCJ helicase mutations are known to cause hereditary breast and ovarian cancers as well as bone marrow failure syndrome Fanconi anemia. FANCJ plays an important role in the repair of DNA inter-stran

NIAID Data Ecosystem10

Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins

精子细胞凋亡

减数分裂调控

Cyclin A1 (Ccna1), a member of the mammalian A type cyclins, is most abundantly expressed in spermatocytes and is essential for spermatogenesis in the mouse. Ccna1- deficient spermatocytes arrest at l

Figshare2017-03-17 更新10

The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles [m6A-Seq]. The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles [m6A-Seq]

RNA甲基化机制

减数分裂调控

N6-methyladenosine (m6A), the most abundant mRNA modification, is deposited in mammals/insects/plants by m6A methyltransferase complexes (MTC) comprising a catalytic subunit and at least five addition

NIAID Data Ecosystem10

The checkpoint clamp protein Rad9 facilitates DNA-end resection and prevents alternative non-homologous end joining

DNA损伤修复

同源重组机制

DNA damage activates the cell cycle checkpoint to regulate cell cycle progression. The checkpoint clamp (Rad9-Hus1-Rad1 complex) is recruited to damage sites, and is required for checkpoint activation

Figshare2016-01-19 更新10

Budding yeast ATM/ATR contribute to meiotic double-strand-break (DSB) homeostasis by down-regulating Rec114, an essential component of the DSB-machinery

资源简介：

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