Pd(II)/β-ICD-Cocatalyzed Asymmetric Route to Oxindole Scaffold via Cascade Reaction of Diazoacetamides and MBH-Carbonates
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https://figshare.com/articles/dataset/Pd_II_-ICD-Cocatalyzed_Asymmetric_Route_to_Oxindole_Scaffold_via_Cascade_Reaction_of_Diazoacetamides_and_MBH-Carbonates/3796095
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资源简介：
We
report an efficient method for asymmetric synthesis of chiral
oxindoles. Allyl palladium(II) chloride dimer (APC)-catalyzed, in
combination with β-isocupreidine (β-ICD)-cocatalyzed,
reaction of diazoacetamide with Morita–Baylis–Hillman
(MBH) carbonates proves to be a facile protocol to access multifunctional
oxindoles bearing a C-3 quaternary stereo center. This tandem reaction
tolerates a wide variety of functional groups on the both aromatic
rings. This method delivers a variety of chiral oxindoles in 50–75%
yield and with up to 95:5 dr in most cases along with up to 93:7 er.
创建时间：
2016-09-12
