Molecular mechanism of nodosin inhibiting colorectal cancer revealed based on transcriptomic analysis

NIAID Data Ecosystem2026-03-14 收录

结肠癌药物机制

组学药物发现

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https://www.ncbi.nlm.nih.gov/sra/SRP371838 数据链接链接失效反馈

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The study could help develop potential treatments based on nodosin

创建时间：

2022-12-30

Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXR-gamma activation. Homo sapiens

结肠癌药物机制

肿瘤免疫调节

Tumor metastasis and lack of NKG2D ligand (NKG2DL) expression are associated with poor prognosis in patients with colon cancer. Here we found that spironolactone (SPIR), an FDA-approved diuretic drug

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Pramanicin Analog Induces Apoptosis in Human Colon Cancer Cells: Critical Roles for Bcl-2, Bim, and p38 MAPK Signaling

结肠癌药物机制

细胞信号通路

Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs fo

NIAID Data Ecosystem40

Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations

癌症联合药物机制

组学药物发现

Acute myeloid leukemia (AML) poses a major clinical challenge due to its genetic diversity, relapse rates, and chemotherapy toxicity. While rational drug combinations improve efficacy, their mechanism

NIAID Data Ecosystem20

Source data for the manuscript "Chemoproteomics-driven discovery of a covalent inhibitor targeting Cys16 on RhoA in colorectal cancer"

组学药物发现

结直肠癌靶向治疗

Source data for the manuscript "Chemoproteomics-driven discovery of a covalent inhibitor targeting Cys16 on RhoA in colorectal cancer"

DataCite Commons2024-10-02 更新50

Parthenolide induces ROS-dependent cell death in human gastric cancer cells

结肠癌药物机制

癌细胞实验

Excel 1 - The original data-Parthenolide induces ROS-dependent cell death in human gastric cancer cellanalysis. Supplemental Table 1 - Post-hoc Dunn's test for the effect of PN on the cell viability

NIAID Data Ecosystem20

Molecular mechanism of nodosin inhibiting colorectal cancer revealed based on transcriptomic analysis

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