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Phosphoglycerate Dehydrogenase-Mediated Serine Reprogramming Aggravates Macrophage Hyperinflammation in P. aeruginosa Pneumonia

NIAID Data Ecosystem2026-05-10 收录

免疫代谢

细菌性肺炎机制研究

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP643031 数据链接链接失效反馈

官方服务：

资源简介：

RNA sequencing (RNA-seq) analysis to indentify the differentially expressed genes between the serine stimulated and deprived iAMs after PAO1 infection

应用场景：

创建时间：

2025-12-30

免疫代谢

巨噬细胞生态位

Gene expression comparison across CD11b+ cells from Csf2-sufficient and deficient mice. Overall design: Steady state isolated CD11b+ cells from colon lamina propria or solitary isolated lymphoid tissu

NIAID Data Ecosystem70

DataSheet_1_Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.zip

免疫代谢

PD-1联合治疗

IntroductionThe discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows s

NIAID Data Ecosystem30

ADAR1 controls macrophage scavenging and lipid-buffering programs in metabolic tissues

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RNA功能分析

Data Table 1. List of RNA editing events per gene and pathway analysis. Data Table 2. List of DEGs for siADAR1, siADAR1-p150 and overlapping and pathway analysis for each comparison. Data Table 3. L

Zenodo2026-04-15 更新20

D- 2-hydroxyglutarate is an immunometabolite that accumulates in macrophages after TLR activation and inhibits inflammatory responses

免疫代谢

巨噬细胞炎症抑制

Macrophages undergo extensive metabolic rewiring upon activation and this serves many roles beyond the production of energy and anabolic building blocks. So-called immunometabolites that accumulate up

NIAID Data Ecosystem30

Additional file 2 of DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

病毒感染表观遗传学

免疫代谢

Additional file 2. Supplementary Table 1. Description of animals used for characterization of DNA methylation during SIV infection.

NIAID Data Ecosystem30