AJP-Endo Supplemental Files

These files are the supplemental materials for the manuscript, "Influence of Metformin on Exercise Metabolism and Capacity: A Systematic Review and Meta-Analysis" submitted to the American Journal of Physiology: Endocrinology and Metabolism.Figure S1: Cochrane Risk of Bias AssessmentTable S1: Information on sampling techniques for blood markers and blood values of studies in systematic reviewTable S2: Information on sampling techniques for VO2 and RER of studies in systematic reviewFigure S2A: Effects of acute metformin intake on lactate (mmol/L) during exercise above the lactate threshold (LT).Figure S2B: Effects of non-acute metformin intake on lactate (mmol/L) during exercise above the lactate threshold (LT).Figure S3A: Effects of acute metformin intake on glucose (mmol/L) during exercise above the lactate threshold (LT).Figure S3B: Effects of non-acute metformin intake on glucose (mmol/L) during exercise above the lactate threshold (LT).Figure S4: Effects of non-acute metformin intake on insulin (pmol/L) during exercise above the lactate threshold (LT).Figure S5A: Effects of acute metformin intake on absolute VO2peak (L/min) during exercise above the lactate threshold (LT).Figure S5B: Effects of non-acute metformin intake on absolute VO2peak (L/min) during exercise above the lactate threshold (LT).Figure S6A: Effects of acute metformin intake on RER during exercise above the lactate threshold (LT).Figure S6A: Effects of non-acute metformin intake on RER during exercise above the lactate threshold (LT).Table S3. GRADE assessment of each variable in meta-analysis.