MOESM2 of Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells
Samples of Holacanthus passer (voucher no. 274) were purchased from local aquarium and originally imported from La Paz, Mexico. Total genomic DNA was extracted from muscle tissue. Paired-end genomic l
A hereditary cancer syndrome is a genetic predisposition to cancer caused by a germline mutation in cancer-related genes. Identifying the disease-causing variant is important for both the patient and
ObjectiveAdrenal incidentalomas are commonly detected in clinical practice. Despite growing interest in their molecular features, their germline genetic background remains largely unexplored. This stu
Rare mutation detection with next generation sequencing has a considerable potential for diagnostics. Detection of circulating tumor DNA is the forefront application of this approach. The major obstac
