<b>T</b><b>ranscriptional signatures of the whole-brain voxel-wise </b><b>resting-state functional network centrality</b><b> alterations in schizophrenia</b>
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A quantitative meta-analysis was first conducted on 21 datasets, involving 1,057 patients and 1,186 healthy controls, to examine disrupted resting-state functional connectivity in schizophrenia, as measured by whole-brain voxel-wise functional network centrality (FNC). Subsequently, partial least squares regression analysis was employed to investigate the relationship between FNC changes and gene expression profiles obtained from the Allen Human Brain Atlas database. Finally, gene enrichment analysis was performed to unveil the biological significance of the altered FNC-related genes.
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2023-09-06
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