Supplementary Material for: Endoscopic diagnosis of epithelial subtypes of superficial non-ampullary duodenal epithelial tumors using magnifying narrow-band imaging.

Introduction: Superficial non-ampullary duodenal epithelial tumors (SNADETs) include low-grade adenoma (LGA) and high-grade adenoma or carcinoma (HGA/Ca), and are classified into two different epithelial subtypes, gastric-type (G-type) and intestinal-type (I-type). We attempted to distinguish them by endoscopic characteristics including magnifying endoscopy with narrow-band imaging (M-NBI).
Methods: Various endoscopic and M-NBI findings of 286 SNADETs were retrospectively reviewed and compared between G- and I-types and histological grades. M-NBI findings were divided into four patterns based on the following vascular patterns; absent, network, intrastructural vascular (ISV), and unclassified. Lesions displaying a single pattern were classified as mono-pattern and those displaying multiple patterns as mixed-pattern. Lesions showing CDX2 positivity were categorized as I-types and those showing MUC5AC or MUC6 positivity were categorized as G-types based on immunohistochemistry.
Results: Among 286 lesions, 23 (8%) were G-type and 243 (85%) were I-type. More G-type lesions were located oral to papilla (91.3％ vs 45.6％, P

引言：表面非壶腹部十二指肠上皮肿瘤（SNADETs）包括低级别腺瘤（LGA）和高级别腺瘤或癌（HGA/Ca），并分为两种不同的上皮亚型，即胃型（G型）和肠型（I型）。本研究旨在通过内镜特征，包括放大内镜与窄带成像（M-NBI）技术，对其进行区分。研究方法：对286例SNADETs的多种内镜和M-NBI表现进行了回顾性分析，并比较了G型和I型以及组织学分级之间的差异。根据以下血管模式，将M-NBI表现分为四种模式：无血管模式、网络模式、结构内血管（ISV）模式和未分类模式。单一模式表现的病灶被归类为单模式，而表现多种模式的病灶被归类为混合模式。根据免疫组织化学检测，CDX2阳性病灶被归类为I型，而MUC5AC或MUC6阳性病灶被归类为G型。结果：在286个病灶中，23个（8%）为G型，243个（85%）为I型。G型病灶更多位于乳头口上方（91.3％ vs 45.6％，P