miRNAs associated with neurofibrillary tangle score.

Neuropathological examination disclosed total neurofibrillary tangele scores. We binned the data 0–15, in increasing increments, for each subject. Scores were divided into three groups corresponding to low neurofibrillary tangeles score (0–4), moderate neurofibrillary tangeles score (5–9) and high neurofibrillary tangeles score (10–15). Ultimately, neurofibrillary tangle subgroups consisted of stage 1 (n = 73), stage 2 (n = 58) and stage 3 (n = 53) subjects for CSF and stage 1 (n = 71), stage 2 (n = 49) and stage 3 (n = 44) for SER. Ordinal logistic regression analysis (OLR) was implemented in order to fit miRNA expression data across the three ordered groups. Delta AIC quantifies the information loss associated with using each model relative to the best approximating model. We report predictor variables with the lowest Akaike Information Criterion (AIC) and that satisfy assumptions of the OLR. p-Value* is unadjusted.