PFKM promotes the survival of GBM cells under glucose deprivation
收藏国家人口健康科学数据中心2026-06-06 收录
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PFKM is the second rate-limiting step of glycolysis, catalyzing the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate. Here we show, using an orthotopic xenograft glioma mouse model, that PFKM is deubiquitinated and translocated into nucleus upon glucose deficiency, thereby activating fatty acid oxidation (FAO), which sustains tumor cell survival and ultimately promotes GBM development.
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北京蛋白质组研究中心创建时间：
2026-02-15
