Additional file 1 of Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses

Additional file 1: Table S1. Characteristics of genetic instruments of gallstone disease. Table S2. Data sources, sample sizes, number of IVs. Table S3. The detailed search strategy for meta-analysis. Table S4. STROBE-MR checklist of recommended items to address in reports of Mendelian randomization studies. Table S5. Characteristics of included studies in meta-analysis. Table S6. Subgroup analyses for relationship between GSD and CVD. Table S7. Significant local regions after correcting for multiple testing (P < 0.05/2,353). Table S8. Genome-wide significant SNPs identified by cross-trait meta-analysis between gallstone disease and stroke (P-CPASSOC < 5×10-8, single trait P-value < 1×10-3, clumping r2=0.2). Table S9. Genome-wide significant SNPs identified by cross-trait meta-analysis between gallstone disease and coronary artery disease (P-CPASSOC < 5×10-8, single trait P-value < 1×10-3, clumping r2=0.2). Table S10. Linear closest genes of each cross-trait analyses-identified SNP for gallstone disease and stroke. Table S11. Linear closest genes of each cross-trait analyses-identified SNP for gallstone disease and coronary artery disease. Table S12. List of SNPs in the 99% credible set identified from fine-mapping analysis for each CPASSOC-identified locus shared between gallstone disease and stroke. Table S13. List of SNPs in the 99% credible set identified from fine-mapping analysis for each CPASSOC-identified locus shared between gallstone disease and coronary artery disease. Table S14. Results from colocalization analysis for each pleiotropic locus identified from CPASSOC between gallstone disease and stroke. Table S15. Results from colocalization analysis for each pleiotropic locus identified from CPASSOC between gallstone disease and coronary artery disease. Table S16. Significant shared transcriptome-wide association analysis results between gallstone disease and coronary artery disease. Table S17. Baseline characteristics of UK Biobank participants by gallstone disease status during follow-up for stroke. Table S18. Baseline characteristics of UK Biobank participants by gallstone disease status during follow-up for coronary artery disease. Table S19. Observational associations between cholecystectomy and cardiovascular diseases. Table S20. Sex-specific observational associations between gallstone disease and cardiovascular diseases. Table S21. Observational associations between cardiovascular diseases and gallstone disease.