RNA-Sequencing-Based Transcriptomic Analysis Reveals a Role for Annexin-A1 in Classical and Influenza A Virus-Induced Autophagy

Influenza viruses have been shown to use autophagy for their survival. However, the proteins and mechanisms involved in the autophagic process triggered by the influenza virus are unclear. Annexin-A1 is an immunomodulatory protein involved in the regulation of the immune response and Influenza A virus replication. In this study, using CRISPR-Cas9, deletion of ANXA1, combined with the next-generation sequencing, we systematically analyzed the critical role of ANXA1 in Influenza A virus infection as well as the detailed processes governing Influenza A virus infection, such as macroautophagy.