MCoS for scenario 14 in Figure 3.

Five MCoS are identified for the EGFR network model (Figure 4) with respect to scenario 14 in Figure 3. Each MCoS would lead to a perfect fit for this scenario and all five MCoS contain three nodes to be enforced to a certain value. Nodes p90rsk and erk12 are common in all MCoS. Nodes rac_cdc42, sos1_eps8_e3b1, vav2, pi34p2 and pip3 are perturbed respectively in MCoS 1–5. In columns MCoS 1–5, three sub-columns are shown: sub-column “Val” shows the corrected state of the node (the actual MCoS), the entry 1 in sub-column “” indicates that a positive input edge is added to the node in order to alter its state, and the entry 1 in sub-column “” indicates that a negative input edge is added to the node (see Methods section).