Characterization of Primary Patient B-cells under Various Stimulation Conditions

The goal of this project was to compare the effects of differential stimulation of primary patient B-cells with CD40L, CpG, anti-IgM, and IL4 individually and in combination. Additionally, we observed a phenomenon where anti-IgM+CpG treatment resulted in a lymphoma-like phenotype and sought to compare this treatment regimen to the lymphoma cell line HBL-1.