Single-Cell RNA Sequencing Unveils Unique Transcriptomic Signatures of Endothelial Cells and Role of ENO1 in Response to Disturbed Flow

The aim of the present study is to investigate the impacts of disturbed shear (DS) and pulsatile shear (PS) on endothelial cell (EC) at single cell resolution by using the step flow channel. Using single-cell RNA sequencing, this study provides a comprehensive perspective of transcriptomic profiles in ECs responding to both DS and PS in the same step flow chamber.