Gene regulatory markers in pregnant, term non-labouring, labouring, and postpartum myometrium.

We have generated genome-wide binding and expression datasets in uterine smooth muscle (myometrium) from murine models of pregnancy and labour. ChIP-seq and total RNA-seq experiments were conducted to evaluate changes in the genomic and transcriptomic landscape of the myometrium prior to, during, and after labour onset. Examination of total RNA and POL2 enrichment in pregnant and labouring myometrium; examination of euchromatin-associated histone marks (H3K27ac, H3K4me3) in pregnant, term non-labouring, labouring, and postpartum myometrium