Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency

Induced pluripotent stem cells (iPSCs) were generated from a patient with FOXA2 haploinsufficiency (FOXA2+/-iPSCs) as well as healthy individual as a control. Then they were differentiated into into all stages of beta cells to understand the role of FOXA2 during pancreatic beta cell development as described in the article entitled "Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency" by Elsayed AK et al. The dataset represent RNA-seq data generated from pancreatic progenitors (PP2) and endocrine progenitors (EP) derived from control iPSCs (Ctr-iPSCs) and from patient-specific FOXA2 haplo-insufficient iPSCs (FOXA2+/-iPSCs). 

The file name is : Sample name with replicate_overall sample number_read direction_001 where:

- PP2-Ctr R1 and PP2-Ctr R2: Pancreatic progenitors derived from Ctr-iPSCs (control)

-PP2-FOX R1, PP2-FOX R2 and PP2-FOX R3: Pancreatic progenitors derived from FOXA2 haplo-insufficient iPSCs (FOXA2+/-iPSCs).

- EP-Ctr R1 and EP-Ctr R2: Endocrine progenitors derived from Ctr-iPSCs (control)

-EP-FOX R1, EP-FOX R2 and EP-FOX R3: Endocrine progenitors derived from FOXA2 haplo-insufficient iPSCs (FOXA2+/-iPSCs).

- RNA-seq data was generated from two biological replicates in control and three replicates in patient. 

- Read direction: R1 (Forward), R2 (Reverse).