Supplementary information files for Crosslinked p(MMA) particles by RAFT emulsion polymerisation: tuning size and stability

Supplementary information files for article Crosslinked p(MMA) particles by RAFT emulsion polymerisation: tuning size and stability The controlled synthesis of amphiphilic di-block copolymers allows a large array of nanostructures to be created, including block copolymer particles, which have proved valuable for biomedical applications. Despite progress in targeting specific block copolymer architectures, control over the size and stability of spherical particles is less well explored. Here, we report the use of RAFT emulsion polymerisation to synthesise a library of p(MMA) particles, crosslinked with ethylene glycol dimethacrylate and stabilised by brush-like poly(ethylene glycol)-based polymers. We successfully synthesised a range of block copolymer particles, offering stability up to p(MMA)1000, with DLS reporting stable particle diameters of 33–176 nm and PDI 1H NMR relaxometry, demonstrating that the Gd complex was successfully incorporated into the particles. This study will inform the synthesis of core–shell particles with optimised stability and targeted sizes, and show a simple method to incorporate a molecular sensor, generating a macromolecular imaging agent.