<i>C. elegans</i> miRNAs conserved in <i>D. melanogaster</i> and <i>H. sapiens</i>.

73 C. elegans miRNAs have significant identity at their 5′ ends and/or ≥70% similarity over their entire sequences to both fly and human miRNAs. All the 73 C. elegans miRNAs have 5′ related sequences in both flies and humans, whereas 16/73 C. elegans miRNAs are also classified as ≥70% homologous over length to miRNAs in flies and humans. For detail in sequence relationships refer to Figure S1. ˆindicates miRNAs with 5′ end sequence homology present in worms, flies and humans. Superscript 70 denotes miRNAs with ≥70% similarity over full sequence across the three analyzed species. It should be noted that the miRNA registry was extensively modified in the year 2007 (releases 10.0 and 10.1), introducing changes to previous mature miRNA sequences as well as adding new mature miRNA sequences to C. elegans (5), D. melanogaster (75) and human (494) miRNA databases. We performed our analysis using the latest miRBase release (10.1). We elected to use C. elegans sequences as reference anchors because of the general availability of deletions for mir genes.