A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response.

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A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response.

Contribution of the Unfolded Protein Response (UPR) transcription factor XBP1 to brain aging

脑衰老

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In this project we aimed to evaluate the contribution of endoplasmic reticulum stress sensor IRE1 and its downstream transcription factor XBP1s to mammalian brain aging. We compared traits associated

NIAID Data Ecosystem70

Gene expression profiling of chondrodysplasia mutants and isogenic controls during hypertrophic induction from iPSCs. Gene expression profiling of chondrodysplasia mutants and isogenic controls during hypertrophic induction from iPSCs

软骨发育不良

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In order to better understand chondrodysplasia disease mechanisms, we induced hypertrophic chondrocytes from chondrodysplasia-specific iPSCs and analyzed their gene expression profile. This dataset in

NIAID Data Ecosystem40

Ribosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

核糖体翻译错误

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Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about

NIAID Data Ecosystem20

A dynamic unfolded protein response contributes to the control of cortical neurogenesis. Mus musculus

神经发育调控

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The cerebral cortex contains layers of neurons sequentially generated by distinct lineage-related progenitors. At the onset of corticogenesis, the first-born progenitors are apical progenitors (APs) w

NIAID Data Ecosystem40

Transcript-specific translational regulation in the unfolded protein response of Saccharomyces cerevisiae. Saccharomyces cerevisiae

未折叠蛋白反应

翻译调控机制

The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) causes stress and induces the unfolded protein response (UPR) which is characterised in part by the transcriptional

NIAID Data Ecosystem20

A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response.

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