Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration. Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration

Heparanase (Hpa), which cuts the side chain of heparan sulfate (HS) into shorter oligosaccharides, exerts a pro-inflammatory mediator in various inflammatory disorders. However, the function and underlying mechanism of Hpa in acute pancreatitis (AP) remain poorly understood. Here, we investigated the interplay between Hpa and the gut microbiota in the development of AP.