Metabolic pathways altered in subjects with reduced insulin sensitivity (ISIMatsuda <15) in descending order of the number of detected differing metabolites.

a)KEGG pathway number.Pathways with less than 10 metabolites differing between individuals with reduced and normal insulin sensitivity are not shown. By comparing the exact experimental mass signals (threshold set as signal to noise ≥3) with the theoretical masses in MassTRIX, the counts of metabolites were obtained and could be assigned to the different metabolic pathways.