Between-study heterogeneity and random versus fixed effects calculations for polymorphisms that were considered “confirmed” in sensitivity analyses considering the discovery and replication data of each GWA as a separate study.

CI: confidence interval; OR: odds ratioadf = degrees of freedom; not all markers were tested by all 3 investigations in their replication efforts, thus even with splitting the discovery and replication phases, there are fewer than 6 datasets (df = 5) for some variants.