longevity-db/ainciburu2023

这是一个包含约115,000个CD34+造血干细胞和祖细胞（HSPCs）的单细胞RNA测序数据集，这些细胞来自健康的年轻人、老年人以及髓性发育不良综合征（MDS）患者。数据集旨在揭示在生命全程和疾病（MDS）中的造血调节、转录和群体水平变化，使用了高分辨率的单细胞RNA测序和计算建模。数据来源于Ainciburu等人在2023年发表的研究。

This dataset comprises ~115,000 CD34+ hematopoietic stem and progenitor cells (HSPCs) profiled via 10x Genomics single-cell RNA-seq from healthy young, elderly, and myelodysplastic syndrome (MDS) patients. The dataset aims to reveal regulatory, transcriptional, and population-level changes in hematopoiesis across the lifespan and in disease (MDS), using high-resolution single-cell RNA-seq and computational modeling, based on the research by Ainciburu et al. (2023).