H4K20me1/2/3 is dynamically regulated during cell cycle to maintain the genomic stability. Here, we found that depletion of H4K20 di-methyltransferase Suv420h1 in mouse adult MuSCs leads to strong acc

NIAID Data Ecosystem30

Actin R256 mono-methylation is a conserved post-translational modification involved in transcription

肌动蛋白甲基化修饰

转录调控

Nuclear actin has been elusive due to the lack of molecular mechanisms. From actin-containing chromatin remodeling complexes, we discovered an arginine mono-methylation mark on evolutionarily conserve

Alliance of Genome Resources10

Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.

转录调控

表观遗传

The conserved core domain of the TATA binding protein (TBP) interacts with multiple partners forming the complexes required for transcription by RNA Polymerases I, II and III. We use genetically modif

NIAID Data Ecosystem50

The Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Liver

转录调控

肝脏转录组

The aryl hydrocarbon receptor (AHR) is a widely-expressed ligand-dependent transcription-factor that mediates cellular responses to dioxins and other planar aromatic hydrocarbons. Indeed, AHR-null mic

NIAID Data Ecosystem30

Distribution of the binding sites of each RNAP holoenzyme.

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