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The Hippo pathway effector YAP is an essential regulator of submandibular gland ductal progenitor patterning

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To investigate the roles of YAP in the submandibular gland (SMG) epithelium, we compared the gene expression profiles of E15.5 SMGs isolated from Yap-loxP/loxP or Yap-loxP/loxP;Shh-Cre (i.e. Cre recombinase from the Shh promoter) embryos. We collected RNA from E15.5 SMGs isolated from Yap-loxP/loxP and Yap-loxP/loxP;Shh-Cre litter mate mice. Embryonic SMGs from three separate timed matings were used for this experiment.

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