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PNPase inhibition is an effective approach for the treatment of chemical hemorrhagic cystitis

NIAID Data Ecosystem2026-05-01 收录

肿瘤药物靶点验证

疾病治疗机制

数据链接：

https://doi.org/10.7910/DVN/PXKLA5 数据链接链接失效反馈

官方服务：

资源简介：

Data for JCI Insight publication. Mar 8; 9(5):e176103

应用场景：

创建时间：

2024-04-26

黑色素瘤基因功能

肿瘤药物靶点验证

Disruptor of Cell Division Cycle 7 (CDC7) expression is elevated in many cancer types including melanoma. Therefore, we analyzed the role of CDC7 in melanoma. Pharmacological inhibition of CDC7 expres

NIAID Data Ecosystem110

A 3D renal proximal tubule on chip model phenocopies Lowe syndrome and Dent II disease tubulopathy.. A 3D renal proximal tubule on chip model phenocopies Lowe syndrome and Dent II disease tubulopathy.

肾病模型

肿瘤药物靶点验证

Lowe syndrome and Dent II disease are X-linked monogenetic diseases characterised by a renal reabsorption defect in the proximal tubules and caused by mutations in the OCRL gene, which codes for an in

NIAID Data Ecosystem40

EGAS00001003137-sc-20181023 - samples

表观遗传学分析

肿瘤药物靶点验证

There is currently a drive to establish cell based assay systems of greater human biological and disease relevance through the use of well characterised transformed cell lines, primary cells and compl

NIAID Data Ecosystem30

Additional file 10 of PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands

癌症基因组数据

肿瘤药物靶点验证

Supplementary Table 3: Significantly differentially expressed genes between ACC tumors and normal samples. Genes with LFC ≥ 1.5 and ≤ -1.5 were included. Genes labeled in green (top of the list) and o

Figshare2025-01-11 更新50

Thermal Shift Assay Data

蛋白质稳定性

肿瘤药物靶点验证

https://pubmed.ncbi.nlm.nih.gov/33479120/

Figshare2024-05-20 更新30