Markers of antimalarial resistance to drugs used in seasonal malaria chemoprevention. Plasmodium falciparum

Despite scale-up of seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine among children under five years in Burkina Faso, malaria incidence remains high, raising concerns regarding SMC effectiveness and selection of drug resistance. Using a case-control design, we compared the prevalence of genetic polymorphisms associated with antimalarial resistance between parasites infecting children eligible to receive SMC and those infecting older children ineligible to receive SMC.