# Supplementary Data for the Paper "Sexual size dimorphism in mammals is associated with changes in the size of gene families related to brain development"

# Supplementary Data for the Paper "Sexual size dimorphism in mammals is associated with changes in the size of gene families related to brain development"

**Author:** Benjamin Padilla-Morales
**Affiliation:** University of Bath
**Email:** [e-mail]

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## Overview

This repository contains supplementary tables for the article "Sexual size dimorphism is associated with gene family contractions in brain development in mammals" The study investigates gene family size expansions and contractions in relation to brain development and sexual size dimorphism in mammals, employing a comparative genomics approach. Subsequently, we perform a Gene Ontology (GO) enrichment analysis on the gene families experiencing expansion and contraction to uncover the functional significance of associated genes. Additionally, we conduct a gene expression analysis of genes linked to these families to determine their over expression in brain tissue, showing the potential influence of sexual selection on the mammalian brain.

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## Contents

- **Supplementary Figures:** Supplementary figures with corresponding descriptions.
- **Supplementary data 1:** Output from gene family expansion/contraction analysis for sexual size dimorphism, along with their corresponding statistical significance per gene family.
- **Supplementary data 2:** Average gene expression levels of brain areas and other tissues for adults and fetuses.
- **Supplementary data 3:** Entrez Gene ID to GO category per gene with foldchange results and p-values
- **Supplementary data 4:** List of species used in the analysis with phenotypical data, including sources.
- **Supplementary data 5:** List of sequences with respective species used for the orthology mapping analysis and links to ftp with download code.
- **Supplementary data 6:** Output from gene family expansion/contraction analysis including zero variance gene families for sexual size dimorphism.
- **Supplementary data 7:** List of species with encephalization index used in this research, along with references.
- **Supplementary table 1:** List of terms, abbreviations, and descriptions of brain structures used for sex-biased gene expression in temporal brain analysis.

For any questions or inquiries, please contact Benjamin Padilla-Morales at the provided email address.

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