Crystal structure and anti-liver cancer activity of two Zn(II) coordination polymers based on N-donor and O-donor co-ligands

Mixed ligand approach has been successfully applied to design coordination polymers with diversiform architectures. In this study, two novel mixed-ligand Zn(II)-based coordination polymers [Zn(bdc)(bib)](H2O)3 (1, H2bdc = 1,4-dicarboxybenzene, bib = 1,3-bis(imidazol-1-yl)benzene) and [Zn(NH2-bdc)(bib)](H2O)2 (2, NH2-H2bdc = 2-amino-1,4-dicarboxybenzene) have been successfully prepared based on zinc nitrate, N-containing ligand and linear carboxylate ligand at the same hydrothermal condition. The anti-viability of compounds 1 and 2 against SMMC-7721 liver cancer cells was assessed with CCK-8 detection kit. Besides, the cell apoptosis and ROS detection experiments were also performed to study the related mechanism about the anticancer activity of compounds 1 and 2.