Appendix III: Crossover activity

PhD thesis: PRDM9 Diversity, Recombination Landscapes and Childhood Leukaemia by Ihthisham Ali Appendix III contains hotspot activity analysis data on DNA3 and AA hotspots in a MHCII sub-region. These data is indicative of the local recombination profile in the MHCII and provides confirmatory evidence for the differential activation of PRDM9 A and a subset of Ct alleles for these two hotspots. Additionally, these data provide fine-scale information on the morphology of the AA hotspot.A. DNA3 hotspot CO activity dataB. DNA3 hotspot Chi-Squared TestC. AA hotspot CO activity dataD. AA hotspot d257 (20) breakpoint mappingE. AA hotspot d257 (20) hotspot morphology graph data

博士学位论文：伊赫萨姆·阿里著《PRDM9 多样性、重组景观与儿童白血病》附录三包含了对 MHCII 亚区中 DNA3 和 AA 热点活动数据分析数据。这些数据揭示了 MHCII 区域的局部重组图谱，并为 PRDM9 A 亚基及其在这些两个热点上的部分 Ct 等位基因的差异激活提供了确凿证据。此外，这些数据还提供了 AA 热点形态学的精细信息。包括：A. DNA3 热点 CO 活动数据；B. DNA3 热点卡方检验；C. AA 热点 CO 活动数据；D. AA 热点 d257 (20) 断点映射；E. AA 热点 d257 (20) 热点形态学图表数据。