肿瘤多功能诊疗一体化纳米探针数据集

纳米分子影像探针是分子影像发展和应用的研究前沿和热点，其具有更好的肿瘤靶向性、更长的癌灶富集时间、更高的成像信噪比和体内稳定性；并且，纳米探针可实现智能响应肿瘤微环境，产生声、光、核、磁等多模态成像信号，实现病灶的高特异性诊疗一体化。其中，光声成像、磁共振成像、磁粒子成像等多模态信号可以在组织、细胞和亚细胞水平上显示特定的分子，评估体内分子水平的变化，并对分子的生物学行为进行定性和定量的成像研究，在细胞和分子水平上检测到特定的组织病理生理学变化，从而实现肿瘤演进的可视化；光学成像可用于术中导航，精准识别肿瘤边界，辅助临床医生更准确地定位癌灶，进行精准切除，从而改善患者预后。

Nanomolecular imaging probes represent the research frontier and hotspot in the development and application of molecular imaging. They feature superior tumor targeting, longer tumor accumulation duration, higher imaging signal-to-noise ratio (SNR) and better in vivo stability. Moreover, these nanoprobes can smartly respond to the tumor microenvironment to generate multimodal imaging signals including acoustic, optical, nuclear and magnetic ones, enabling highly specific theranostic integration of lesions. Multimodal signals such as photoacoustic imaging, magnetic resonance imaging (MRI) and magnetic particle imaging (MPI) can visualize specific molecules at the tissue, cellular and subcellular levels, evaluate in vivo molecular-level changes, conduct qualitative and quantitative imaging studies on the biological behaviors of molecules, and detect specific tissue pathophysiological changes at the cellular and molecular levels, thereby achieving the visualization of tumor progression. Optical imaging can be applied for intraoperative navigation to accurately identify tumor boundaries, assist clinicians in more precisely localizing tumor foci and performing precision resection, thus improving patient prognosis.

搜集汇总

背景与挑战

背景概述

该数据集聚焦于肿瘤多功能诊疗一体化纳米探针的研究，包含纳米分子影像探针在肿瘤靶向性、多模态成像（如光声和磁共振成像）和诊疗一体化方面的实验数据，用于肿瘤演进可视化和术中导航。数据集由厦门大学、珠海市人民医院和中国科学院自动化研究所联合创建，数据量达42.42GB，包含23609个文件，源自国家重点研发计划项目，旨在支持肿瘤分子影像和精准医疗领域的研究与应用。