Investigating microbiome patterns that precede onset of morbidity and mortality in people with HIV

Antiretroviral therapy (ART) has dramatically improved survival rates among people with HIV (PWH), but this population continues to experience heightened rates of inflammation-related comorbidities. Inflammation in PWH is associated with alterations in microbiome composition, though whether such alterations precede inflammation-related comorbidities or occur as their consequence, remains poorly understood. We performed 16S rRNA sequencing on stool of PWH 1-2 years prior to onset of morbidity or mortality as well as matched control PWH to identify microbiome patterns that precede HIV disease progression. Contact: Ivan Vujkovic-Cvijin. This submission was powered by METAGENOTE (https://metagenote.niaid.nih.gov).