Additional file 1: of Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies

Table S1. Reactions modified to curate the Plasmodium falciparum genome-scale metabolic model. (ST2A and ST2B) Table S2. Down-regulated Differentially Expressed Genes in (A) Short and (B) Long-term Chloroquine-treated Parasites. The gene IDs, corresponding gene names, and fold changes of significantly down-regulated genes in response to chloroquine treatment. Table S3. Up-regulated Differentially Expressed Genes in (A) Short and (B) Long-term Chloroquine-treated Parasites. The gene IDs, corresponding gene names, and fold changes of significantly up-regulated genes in response to chloroquine treatment. Table S4. Significant Down Regulation of Metabolic Genes Arising from Chloroquine Treatment. A: Metabolic DEGs Common to Long and Short-term Treated Conditions. B: Metabolic DEGs Unique to Short-term Treated Condition. The gene IDs, corresponding gene names, and metabolic subsystems of genes with significant expression changes in response to chloroquine treatment. C: Metabolic DEGs Unique to Long-term Treated Condition. The gene IDs, corresponding gene names, and metabolic subsystems of genes with significant expression changes in response to chloroquine treatment. Table S5. Reactions Essential in only Chloroquine-Treated Models. The reaction IDs, corresponding enzyme names, reaction formulas, and metabolic subsystems of essential reactions common to chloroquine-treated condition models constructed with varying growth thresholds (30–80%). Table S6. Reactions Essential in only the Short-Term Treatment Condition. Table S7. Reactions Essential in only the Long-Term Treatment Condition. Table S8. Flux Values for Isoprenoid Metabolism Reactions. Results represent median flux values across condition models constructed with varying growth thresholds (30–80%). Bolded reactions are represented in Fig. 4. Table S9. Flux Values for Folate Metabolism Reactions. Results represent median flux values across condition models constructed with varying growth thresholds (30–80%). Bolded reactions are represented in Fig. 5. (ODS 28 kb)