A Stability-Constrained Phase-Dependent AR(2) Framework for Discovering Cross-Tissue Circadian Gating Architectures

PAR(2) Discovery Engine: A Phase-Gated Autoregressive Framework for Circadian Cancer Research This dataset accompanies the manuscript "A Phase-Gated AR(2) Framework Reveals Circadian 'Gatekeeper Switching' During Cancer Progression." PAR(2) quantifies how circadian clock gene phase modulates expression dynamics of cancer-relevant target genes. Key findings across 84,279 statistical tests: Systematic "gatekeeper switching" in intestinal organoids: healthy tissue gates developmental regulators; BMAL1 loss triggers compensatory stem-cell protection; APC mutation abolishes circadian gating MYC-activated neuroblastoma recruits all 7 clock genes to gate PPARG metabolism Multi-omics proteomics reveals 48 FDR-significant protein-level findings, with HIF1A (hypoxia master regulator) showing the largest effect (f² = 18.44) through purely post-transcriptional circadian control Includes: Complete PAR(2) results for mRNA (83,055 tests across 11 datasets), proteomics (464 tests), and mRNA-protein concordance analysis (760 comparisons).